Barcelona forward Lionel Messi reached another milestone in his phenomenal career on Sunday when he set a record for goals scored in a calendar year of 86 with a La Liga double at Real Betis, beating Gerd Mueller's 40-year-old tally of 85.
Samuel Eto'o scored twice to help Barcelona rally from two down to draw 2-2 at Real Betis on Saturday, stretching their Primera Liga lead to 13 points.
Cristiano Ronaldo scored a hat-trick and Real Madrid rattled in four goals before halftime in a 5-1 La Liga rout of Real Sociedad at the Bernabeu in Madrid.
Costa, Alba excluded from Spain squad
Leaders Barcelona and second-placed Atletico Madrid took full advantage of Real Madrid's stumble on Sunday, Barca winning 4-0 at Levante and Atletico thumping visiting Sevilla by the same scoreline at the Calderon.
Barcelona dealt a stinging blow to Real Madrid's title hopes when Luis Suarez and Neymar continued their scintillating form to fire the champions to a stunning 4-0 victory in the La Liga 'Clasico' on Saturday.
'Barca are the best team around and when we play as we know how we are unstoppable'
Manchester United ended Arsenal's 15-game unbeaten away run in all competitions with a 1-0 Premier League win at Old Trafford. Unbeaten Barcelona moved three points clear in La Liga with a 4-1 victory at Real Betis, while Cristiano Ronaldo grabbed a hat-trick in Real Madrid's 5-1 win over Real Sociedad. Bayern Munich extended their unbeaten record to 37 games with a 3-0 triumph over Augsburg in the Bundesliga.
The three Premier League and three La Liga clubs in the last eight avoided each other, with Manchester City up against Atletico Madrid and Liverpool to face Portuguese side Benfica.
Real Madrid dug deep in a 3-0 home win against lowly Alaves in the La Liga, but Ligue 1 leaders Paris St Germain their second Ligue 1 loss of the season.
Real Madrid extended their unbeaten run to 25 matches and rejoined Barcelona and Atletico Madrid at the top of La Liga when Jese, Karim Benzema and Luka Modric scored in a 3-0 win at Getafe on Sunday.
Barcelona said captain Iniesta would miss the match after he was not able to train with his team mates on Tuesday ahead of the encounter at the Santiago Bernabeu, where the Catalans will look to overturn a 3-1 deficit.
The Real Madrid-Barcelona 'Clasico' is televised around the world and often decides the La Liga title, but a Seville derby is a tougher proposition, Barca defender and former Sevilla favourite Dani Alves has said.
IMAGES from the Europa League matches played on Thursday.
Sevilla became surprise Liga leaders on Sunday after beating visiting Celta Viga 2-1 while champions Barcelona drew 1-1 at Valencia thanks to another Lionel Messi strike but are still without a victory in their last four league games.
A round-up of the weekend's action from Europe's leading leagues.
Carlos Aranda's 90th-minute goal gave Real Zaragoza a 1-0 win at Levante in a King's Cup last 16 first-leg tie on Thursday while Real Betis were held to a 1-1 draw at second division Las Palmas.
In his absence, the league champions have made a lacklustre start to the season, losing their opening game to Athletic Bilbao before taking just four points from fixtures against Real Betis and Osasuna.
News of all that's transpired on and off the football field
News of all that transpired on and off the football field.
Midfielder Cesc Fabregas moved Barcelona a step closer to the La Liga title with a late strike in a laboured 1-0 victory at home to mid-table Levante on Saturday.
Ajax, four-times European Cup winners who are in the knockout stages for the first time in 13 years, have enhanced their reputation as a talent factory due to the rise of homegrown Dutch players Frenkie de Jong and Matthijs de Ligt.
I arrived at Seville airport wearing a shirt with the badge of Ukraine. This journalist reported that I was wearing a shirt from a paramilitary group, whose badge is distinguished from the badge of my country, claims Ukraine forward Roman Zozulya.
Barcelona had to come from a goal down to rescue a 1-1 draw at mid-table Levante on Sunday, leaving Atletico Madrid with a chance to go top of La Liga.
Barcelona midfielder Cesc Fabregas will be out for three to four weeks after damaging a thigh muscle in the early stages of Sunday's 2-1 La Liga win at Real Betis.
South Haryana hasn't delivered a chief minister since 1967, when his father Rao Birender Singh was ousted from power. It's a legacy Rao Inderjit Singh is determined to reclaim.
Bachchan said, "It's time we realise that half of the country's population can't be left behind by making them feel neglected and helpless. They should be equal partners in the country's development."
Joining them in the last four were Getafe and Deportivo Coruna.
Luis Suarez struck twice and Lionel Messi scored on his 500th appearance for Barcelona who set a new Spanish record of goals in a calendar year with a 4-0 win over Real Betis that lifted them top of La Liga on Wednesday.
Rennes denied late Europa League equaliser due to little-known rule
Mario Gomez dusted off his shooting boots to put Fiorentina in the driving seat with a 1-1 Europa League draw at Juventus while Benfica were too good for Tottenham Hotspur, winning their last-16 first leg 3-1 away on Thursday.
"We have nothing to argue with, we have no defence because our performance in the first half was so bad," Mourinho said.
Real Madrid made it two wins in two La Liga outings this season when Karim Benzema's scuffed 10th-minute strike secured an uninspiring 1-0 win at Granada on Monday.
Barcelona's players will bear the city's name on the back of their shirts in tribute to the victims of Thursday's deadly attack in the Catalan capital when they play Real Betis in La Liga on Sunday, the club said in a statement.